{"id":1793,"date":"2021-01-19T10:56:53","date_gmt":"2021-01-19T08:56:53","guid":{"rendered":"https:\/\/dermitzaki.gr\/?p=1793"},"modified":"2022-09-22T18:57:38","modified_gmt":"2022-09-22T15:57:38","slug":"a%cf%80%ce%bf%ce%bb%ce%b9%cf%80%ce%bf%cf%80%cf%81%cf%89%cf%84%ce%b5%ce%90%ce%bd%ce%b7-%ce%b5-apoe-%ce%ba%ce%b1%ce%b9-%ce%ac%ce%bd%ce%bf%ce%b9%ce%b1","status":"publish","type":"post","link":"https:\/\/dermitzaki.gr\/sq\/a%cf%80%ce%bf%ce%bb%ce%b9%cf%80%ce%bf%cf%80%cf%81%cf%89%cf%84%ce%b5%ce%90%ce%bd%ce%b7-%ce%b5-apoe-%ce%ba%ce%b1%ce%b9-%ce%ac%ce%bd%ce%bf%ce%b9%ce%b1\/","title":{"rendered":"ALIPOPROTEIN E (ApoE) DHE DEMENCI"},"content":{"rendered":"<h2>Apolipoproteinat<\/h2>\n<p>Apolipoproteinat (Apo) dallohen n\u00eb ApoAI, ApoAII, ApoAIV, ApoB48 dhe B100, ApoCII, ApoCIII dhe ApoE. N\u00eb m\u00ebnyr\u00eb t\u00eb ve\u00e7ant\u00eb, apolipoproteina E (ApoE) \u00ebsht\u00eb nj\u00eb protein\u00eb n\u00eb plazm\u00ebn e njeriut dhe funksioni i saj kryesor konsiston n\u00eb pjes\u00ebmarrjen e saj n\u00eb metabolizmin e lipideve. \u00cbsht\u00eb nj\u00eb element strukturor i kilomikroneve, VLDL, LDL dhe nj\u00eb n\u00ebngrup i lipoproteinave HDL. Megjithat\u00eb, shp\u00ebrndahet edhe n\u00eb t\u00eb gjitha zonat e trurit, nd\u00ebrsa sintetizohet dhe sekretohet kryesisht nga qelizat gliale, ve\u00e7an\u00ebrisht nga astrocitet.<\/p>\n<h2>Alzheimer<\/h2>\n<p>ApoE intraneuronal \u00ebsht\u00eb identifikuar n\u00eb trurin e njeriut t\u00eb individ\u00ebve t\u00eb sh\u00ebndetsh\u00ebm dhe individ\u00ebve me s\u00ebmundjen Alzheimer. ApoE \u00ebsht\u00eb apolipoproteina kryesore n\u00eb l\u00ebngun cerebrospinal, ku qarkullon si nj\u00eb lipoprotein\u00eb e vog\u00ebl globulare dhe diskoide, duke transportuar kolesterolin dhe fosfolipidet midis qelizave p\u00ebr t\u00eb ruajtur homeostaz\u00ebn n\u00eb mjedisin e trurit.<\/p>\n<p>Gjeni i shprehur nga ApoE ndodhet n\u00eb kromozomin 19 dhe \u00ebsht\u00eb polimorfik, pra ka tre forma dhe krijon tre forma t\u00eb ApoE (\u03b52, \u03b53, \u03b54). K\u00ebshtu krijohen 6 gjenotipe (\u03b52\/\u03b52, \u03b53\/\u03b53, \u03b54\/\u03b54, \u03b52\/\u03b53, \u03b52\/\u03b54, \u03b53\/\u03b54), q\u00eb do t\u00eb thot\u00eb se \u00e7do person ka n\u00eb gjenet e tij nj\u00eb nga kombinimet e m\u00ebsip\u00ebrme. Forma \u03b54 e ApoE \u00ebsht\u00eb shoq\u00ebruar me nivele duksh\u00ebm m\u00eb t\u00eb larta t\u00eb kolesterolit n\u00eb gjak<br \/>\nnjer\u00ebzore n\u00eb krahasim me njer\u00ebzit q\u00eb kan\u00eb ApoE \u03b53 dhe \u03b52. Tani dihet se njer\u00ebzit q\u00eb jan\u00eb homozigot\u00eb t\u00eb ApoE \u03b54 (d.m.th. kan\u00eb \u03b54\/\u03b54), kan\u00eb 40% nj\u00eb rrezik m\u00eb t\u00eb lart\u00eb n\u00eb krahasim me njer\u00ebzit q\u00eb mbartin nj\u00eb form\u00eb tjet\u00ebr t\u00eb protein\u00ebs p\u00ebr s\u00ebmundje koronare t\u00eb zemr\u00ebs, sepse qarkullojn\u00eb m\u00eb shum\u00eb kolesterol n\u00eb gjakun e tyre dhe e krijojn\u00eb at\u00eb. pllaka ateromatoze me lehte. Gjithashtu bart\u00ebsit e k\u00ebtij gjeni kan\u00eb nj\u00eb m\u00eb t\u00eb madhe<br \/>\nmund\u00ebsia e zhvillimit t\u00eb s\u00ebmundjes Alzheimer p\u00ebr shkak t\u00eb rritjes s\u00eb akumulimit t\u00eb amiloidit oligomerik neurotoksik A\u03b2 dhe krijimit t\u00eb pllakave amiloide n\u00eb Sistemin Nervor Qendror q\u00eb jan\u00eb karakteristik\u00eb e s\u00ebmundjes.<\/p>\n<p>K\u00ebshtu, personat q\u00eb jan\u00eb bart\u00ebs t\u00eb gjenit ApoE-\u03b54 (sidomos homozigot\u00ebt) dhe n\u00ebse kan\u00eb edhe raste t\u00eb s\u00ebmundjes Alzheimer n\u00eb familjen e tyre, paraqesin rrezik m\u00eb t\u00eb lart\u00eb t\u00eb zhvillimit t\u00eb demenc\u00ebs n\u00eb krahasim me personat q\u00eb nuk kan\u00eb ApoE-\u03b54. N\u00eb SHBA, sipas Raber et al., rreth 231 TP3T e popullat\u00ebs s\u00eb p\u00ebrgjithshme jan\u00eb bart\u00ebs t\u00eb ApoE-e4 (heterozigot\u00eb) dhe 2 % jan\u00eb homozigot\u00eb ApoE-e4. Nd\u00ebrsa<br \/>\nvler\u00ebsohet se 65% e pacient\u00ebve me s\u00ebmundje Alzheimer bartin ApoE-\u03b54.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u039f\u03b9 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u039f\u03b9 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 (Apo) \u03b4\u03b9\u03b1\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 ApoAI, ApoAII, ApoA\u0399V, ApoB48 \u03ba\u03b1\u03b9 \u0392100\u00b7 ApoCI, ApoCII, ApoCIII, \u03ba\u03b1\u03b9 ApoE. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b7 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u0395 (ApoE) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c3\u03c4\u03bf \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd. \u0395\u03af\u03bd\u03b1\u03b9 \u03b4\u03bf\u03bc\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03c4\u03c9\u03bd \u03c7\u03c5\u03bb\u03bf\u03bc\u03b9\u03ba\u03c1\u03ce\u03bd, \u03c4\u03c9\u03bd VLDL, \u03c4\u03c9\u03bd LDL \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1\u03c2 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03c4\u03c9\u03bd HDL [&hellip;]<\/p>","protected":false},"author":3,"featured_media":1862,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"class_list":["post-1793","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-53"],"_links":{"self":[{"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/posts\/1793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/comments?post=1793"}],"version-history":[{"count":5,"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/posts\/1793\/revisions"}],"predecessor-version":[{"id":2472,"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/posts\/1793\/revisions\/2472"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/media\/1862"}],"wp:attachment":[{"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/media?parent=1793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/categories?post=1793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dermitzaki.gr\/sq\/wp-json\/wp\/v2\/tags?post=1793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}